DAO-HIST
DAO-Hist – Patented Diamine Oxidase (DAO) Enzyme Formula for Supporting Healthy Degradation of Food-Derived Histamine
Histamine is a naturally occurring compound involved in immune responses, digestion, and neurotransmission, but excess ingested histamine from certain foods (e.g., aged cheeses, fermented items, wine, or processed meats) can overwhelm the body's natural breakdown pathways, leading to occasional discomfort like flushing, headaches, or digestive unease in sensitive individuals. Diamine oxidase (DAO) is the primary enzyme responsible for degrading dietary histamine in the digestive tract before it enters systemic circulation.
DAO-Hist provides a clinically tested, patented source of DAO enzyme derived from porcine kidney protein concentrate—delivering 20,000 HDU (histamine degrading units) per tablet. This targeted enzyme acts locally in the gut to enhance the presence and activity of DAO, supporting efficient breakdown of food-derived histamine without systemic absorption or effects. It is not intended for IgE-mediated food allergies, immune-related reactions, or gluten intolerance/celiac disease.*
Key Benefits
Supports Healthy Degradation of Ingested Histamine The patented DAO enzyme specifically targets and breaks down histamine from food sources in the digestive tract, helping reduce the potential for histamine-related discomfort after consuming histamine-rich meals.*
Enhances Diamine Oxidase Presence in the Digestive Tract By supplementing with bioavailable DAO, this formula bolsters the body's natural capacity to handle dietary histamine load—promoting smoother digestion and comfort for those with occasional histamine sensitivity from foods.*
Why This Patented DAO Enzyme?
Sourced from porcine kidney and standardized to deliver a clinically relevant 20,000 HDU per serving, this DAO is the same form used in research demonstrating its ability to degrade histamine locally in the gut. Unlike systemic antihistamines, it works enzyme-to-substrate in the digestive environment for targeted support—delivered in a convenient tablet format taken shortly before meals for optimal timing and efficacy.*
Supplement Facts
Serving Size: 1 Tablet Servings Per Container: 60
| Amount Per Serving | % Daily Value | |
|---|---|---|
| Diamine Oxidase (from porcine kidney protein concentrate) | 600 mcg (20,000 HDU) | ** |
** Daily Value not established.
Other Ingredients Microcrystalline cellulose, HPMC (capsule), sucrose, ascorbic acid, rice starch, shellac, hydroxypropylcellulose, polyvinylpolypyrrolidone, hydrated magnesium silicate, acetylated corn starch, sodium carboxymethylcellulose, and glycerol.
Does Not Contain Gluten, dairy, soy, artificial colors, sweeteners, or preservatives. Made in a GMP-compliant facility.
Suggested Use Take one to two tablets no more than 15 minutes before the consumption of histamine-rich foods, or as directed by your healthcare professional.
Cautions Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Avoid if allergic to pork or any other ingredient. DAO-Hist is NOT effective for symptoms of immune-related food allergies (such as peanuts, shellfish, etc.) or for gluten intolerance due to sensitivity or celiac disease. If you are pregnant or nursing, consult your physician before taking this product. Keep out of reach of children. Do not use if tamper seal is damaged.
Navigate histamine-rich foods with confidence. DAO-Hist – because targeted enzyme support helps keep dietary histamine in check.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.