Methyl b12 + 5-MTHF
Great-Tasting Cherry Chewable with Quatrefolic® (6S)-5-MTHF and Methylcobalamin for Optimal Methylation, Nervous System Health, and Cellular Energy Support
Methylation is a fundamental biochemical process that influences DNA repair, neurotransmitter production, detoxification, hormone balance, and red blood cell formation. Many people have genetic variations (e.g., MTHFR polymorphisms) that impair conversion of folic acid to its active form, 5-MTHF, leading to suboptimal folate status despite adequate intake. Methyl B12 + 5-MTHF Ortho NG delivers Quatrefolic®—the glucosamine salt of (6S)-5-methyltetrahydrofolate—the most bioavailable, directly active form of folate that raises plasma folate levels more effectively than folic acid—paired with high-potency methylcobalamin (the active, tissue-ready form of B12).
In a delicious, naturally flavored cherry chewable tablet, this formula bypasses conversion steps for efficient methylation support, helps maintain healthy homocysteine levels, supports nervous system function, promotes normal cellular proliferation (including red blood cells), and avoids unmetabolized folic acid accumulation—ideal for daily methylation maintenance, energy, mood balance, and cognitive wellness.*
Key Benefits
Supports Optimal Methylation Pathways Quatrefolic® 5-MTHF and methylcobalamin provide ready-to-use forms that directly participate in the methylation cycle—helping convert homocysteine to methionine and supporting SAMe production for neurotransmitter, DNA, and detoxification pathways.*
Promotes Healthy Nervous System Function Methylcobalamin supports myelin sheath integrity and nerve signaling, while active folate aids neurotransmitter synthesis—contributing to mental clarity, mood stability, and neurological comfort.*
Supports Normal Cellular Proliferation (Including Red Blood Cells) Both nutrients are essential for DNA synthesis and red blood cell maturation—helping maintain healthy hemoglobin levels, oxygen transport, and overall cellular vitality.*
Does Not Contribute to Unmetabolized Folic Acid Accumulation (UMFA) Quatrefolic® is already in the active (6S)-5-MTHF form, bypassing the need for enzymatic conversion and avoiding potential buildup of unmetabolized folic acid seen with synthetic folic acid.*
Supports Healthy Serum Folate Levels Clinical data shows Quatrefolic® increases plasma folate more effectively than folic acid—providing reliable support for folate status, even in those with conversion challenges.*
Why Quatrefolic® + Methylcobalamin in a Chewable?
Quatrefolic® is a patented, glucosamine-stabilized form of (6S)-5-MTHF with superior bioavailability and stability compared to calcium salt forms or folic acid. Methylcobalamin is the preferred, coenzyme-active B12 for direct utilization. The great-tasting cherry chewable offers convenient, enjoyable dosing without swallowing large capsules—perfect for daily methylation and energy support in a clean, allergen-free formula.*
Supplement Facts
Serving Size: 1 Tablet Servings Per Container: 60
| Amount Per Serving | % Daily Value | |
|---|---|---|
| Folate (from 1,000 mcg as Quatrefolic® (6S)-5-methyltetrahydrofolic acid, glucosamine salt) | 1,700 mcg DFE | 425% |
| Vitamin B12 (as Methylcobalamin) | 5,000 mcg | 208,333% |
** Daily Value not established.
Other Ingredients Isomalt, natural cane sugar, croscarmellose sodium, potassium bicarbonate, natural cherry flavor (MSG-free), sodium stearyl fumarate, stearic acid, citric acid, silicon dioxide, and bilberry fruit extract.
Does Not Contain Gluten, yeast, artificial colors, or flavors. Formulated to be free of common allergens.
Suggested Use Take 1 tablet per day or as recommended by your healthcare professional.
Cautions If you are pregnant or nursing, consult your physician before taking this product. Individuals taking medication should discuss potential interactions with their healthcare professional. Keep out of reach of children. Do not use if tamper seal is damaged.
Fuel your methylation cycle with active forms. Methyl B12 + 5-MTHF – because Quatrefolic® and methylcobalamin deliver superior support for energy, mood, and cellular health in a tasty cherry chew.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.